1. L Cui, J. Liu, and K.A. Schleyer. Probes for heparanase. US provisional patent. 2019.


2. L. Cui, J. Liu, Y. Wang, and P. Deenik, Near Infrared small molecule probes for the detection of cellular senescence. US provisional patent. 2017.

3. J. Rao, A. J. Shuhendler, and  L. Cui (Stanford University, USA), Probes For Imaging PARP-1 Activity. US Patent 10,196,412.  

4.     C.-C. Ling, L. Cui, R. Ghosh, P. Zhang, and A-X. Wang (Alberta Glycomic Center, Canada), Amphiphilic Cyclodextrin-based Glycodendrimers. CA-2962297. US-9950080-B2. EP-3052530-B1. WO2015048897A1.



Molecular probes for selective detection of cysteine cathepsins, Schleyer, Kelton A., and Lina Cui, Organic & Biomolecular Chemistry (2021).


Dual-Mechanism Quenched Fluorogenic Probe Provides Selective and Rapid Detection of Cathepsin L Activity,
Kelton A. Schleyer, Ben Fetrow, Peter Zannes Fatland, Jun Liu, Maya Chaaban, Biwu Ma, Lina Cui, ChemMedChem (2020)


Ultrasensitive small molecule fluorogenic probe for human heparanase, Jun Liu, Kelton A. Schleyer, Tyrel L. Bryan,   Changjian Xie, Gustavo Seabra, Yongmei Xu, Arjun Kafle,  Chao Cui, Ying Wang, Kunlun Yin, Benjamin Fetrow, Paul K. P. Henderson, Peter Z. Fatland, Jian Liu, Chenglong Li, Hua Guo and  Lina Cui, Chem. Sci, 2020, Advance Article


Reduction Triggered In Situ Polymerization in Living Mice, Lina Cui, Sandro Vivona, Bryan R. Smith, Sri Kothapalli, Jun Liu, Xiaowei Ma, Zixin Chen, Madelynn Taylor, Paul H Kierstead, Jean M. J. Frechet, Sanjiv S. Gambhir, and Jianghong Rao, J. Am. Chem. Soc. 2020


Internally quenched fluorogenic probe provides selective and rapid detection of cathepsin L activity, Kelton A. Schleyer, Ben Fetrow, Peter Zannes Fatland, Jun Liu, Maya Chaaban, Biwu Ma, Lina Cui, ChemBioChem, 2020


A Self-Immobilizing NIR Probe for Non-invasive Imaging of Senescence, Jun Liu, Kelton A. Schleyer, Tyrel Liu, Jun, Xiaowei Ma, Chao Cui, Ying Wang, Philip R. Deenik, and Lina Cui, BioRxiv, 2020


Responsive Fluorophore Aggregation Provides Spectral Contrast for Fluorescence Lifetime Imaging,Kelton A. Schleyer, Dr. Benjamin D. Datko, Brandon Burnside, Chao Cui, Xiaowei Ma, Prof. Dr. John K. Grey, Prof. Dr. Lina Cui,  ChemBioChem, 2020


Responsive Fluorophore Aggregation Provides Spectral Contrast for Fluorescence Lifetime Imaging,
Kelton A. Schleyer, Dr. Benjamin D. Datko, Brandon Burnside, Chao Cui, Xiaowei Ma, Prof. Dr. John K. Grey, Prof. Dr. Lina Cui,  ChemBioChem, 2020


Real-time imaging of senescence in tumors with DNA damageYing Wang, Jun Liu, Xiaowei Ma, Chao Cui, Philip R. Deenik, Paul K. P. Henderson, Ashton L. Sigler & Lina Cui, Scientific Reports volume9, Article number: 2102 (2019) 


[18F]-SuPAR: A Radiofluorinated Probe for Noninvasive Imaging of DNA Damage-Dependent Poly(ADP-ribose) Polymerase Activity
Adam J. Shuhendler, Lina Cui, Zixin Chen, Bin Shen, Min Chen, Michelle L. James, Timothy H. Witney, Magdalena Bazalova-Carter, Sanjiv S. Gambhir, Frederick T. Chin, Edward E. Graves, and Jianghong Rao*,Bioconjugate Chem. 2019, 30, 5, 1331–1342


Controlling the stereoselectivity of glycosylation via solvent effectsArjun Kafle, Jun Liu, Lina Cui Canadian Journal of Chemistry, 2016, 94(11): 894-901

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Caspase-Activated Gadolinium-based Contrast Agent for Magnetic Resonance Imaging of Drug-Induced Tumor Apoptosis in Mice, Deju Ye, Adam J. Shuhendler, Prachi Pandit, Kimberly D. Brewer, Sui Seng Tee, Lina Cui, Grigory Tikhomirov, Brian Rutt* and  Jianghong Rao*, Chem. Sci., 2014,5, 3845-3852 

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Phosphorylcholine-Coated Semiconducting Polymer Nanoparticles as Rapid and Efficient Labeling Agents for In Vivo Cell Tracking, Kanyi Pu, Adam J. Shuhendler, Maija P. Valta, Lina Cui, Matthias Saar, Donna M. Peehl, and Jianghong Rao*, Adv. Healthcare Mater., 2014, 3: 1292–1298.


Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo, Deju Ye, Adam J. Shuhendler, Lina Cui, Ling Tong, Sui Seng Tee, Grigory Tikhomirov, Dean W. Felsher & Jianghong Rao*, Nature Chemistry 6, 519–526 (2014) 


Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing, Adam J Shuhendler, Kanyi Pu, Lina Cui, Jack P Uetrecht & Jianghong Rao*, Nature Biotechnology. 2014, 32: p. 373-380. Also highlighted in News and Views of Nature Biotechnology (same issue).

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Chemical Methodology for Labelling and Bioconjugation. Lina Cui* and Jianghong Rao, Chemistry of Molecular Imaging, P 25-53.


2‑Cyanobenzothiazole (CBT) Condensation for Site-Specific Labeling of Proteins at the Terminal Cysteine Residues, Lina Cui* and Jianghong Rao, Site-specific protein labeling: Methods and Protocols, 2014, p 81-92.


Synthesis of modified Trichinella spiralis disaccharide epitopes and a comparison of their recognition by chemical mapping and saturation transfer difference NMR, Lina Cui*, Chang-Chun Ling,.Joanna Sadowska, David R. Bundle, Carbohydrate Research. 2014, 383(1): p. 1-13.


First Per-6-O-tritylation of Cyclodextrins, Ping Zhang, Aixia Wang, Lina Cui, and Chang-Chun Ling*, Org. Lett., 2012, 14 (6), pp 1612–1615


Conjugation Chemistry through Acetals toward a Dextran-Based Delivery System for Controlled Release of siRNA, Lina Cui, Jessica L. Cohen, Crystal K. Chu, Peter R. Wich, Paul H. Kierstead, and Jean M. J. Fréchet*, J. Am. Chem. Soc., 2012, 134 (38), pp 15840–15848


Supramolecular complexing of membane Siglec CD22 mediated by a polyvalent heterobifunctional ligand that templates on IgM, Lina Cui, Pavel I. Kitov, Gladys C. Completo, James C. Paulson, and David R. Bundle*, Bioconjugate Chem., 2011, 22 (4), pp 546–550


Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics, Jessica L. Cohen, Stephanie Schubert, Peter R. Wich, Lina Cui, Joel A. Cohen, Justin L. Mynar, and Jean M. J. Fréchet*, Bioconjugate Chem., 2011, 22 (6), pp 1056–1065


Mannosylated Dextran Nanoparticles: A pH-Sensitive System Engineered for Immunomodulation through Mannose Targeting, Lina Cui, Joel A. Cohen, Kyle E. Broaders, Tristan T. Beaudette, and Jean M. J. Fréchet*, Bioconjugate Chemistry, 2011. 22(5): p. 949-957.  

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Synthesis of Monomeric and Dimeric Repeating Units of the Zwitterionic Type 1 Capsular Polysaccharide from Streptococcus pneumoniae, Xiangyang Wu, Lina Cui, ​Tomasz Lipinski, and David R. Bundle* Chemistry-a European Journal, 2010. 16(11): p. 3476-3488.

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From alpha to beta: identification of amino acids required for the N-acetyllactosamine-specific lectin-like activity of bundlin, Romney M. Humphries, Michael S. Donnenberg, Jonathan Strecker, Elena Kitova, John S. Klassen, Lina Cui, Thomas P. Griener, George L. Mulvey and Glen D. Armstrong*, Molecular Microbiology, 2009. 72(4): p. 859-868.