© 2015 by Lina Cui Laboratory at the University of Florida, Gainesville, USA

Xiaowei Ma, M.D., Ph.D.

Research Assistant Professor

M.D. 2007, Bethune Medical School of Jilin University, China

Exchange Scholar, Molecular Imaging, 2013-15, Stanford University

Ph.D. Radiology, 2016, The Fourth Military Medical University, China

1.         Zhang, R.; Cheng, K.; Antaris, A. L.; Ma, X.; Yang, M.; Ramakrishnan, S.; Liu, G.; Lu, A.; Dai, H.; Tian, M.; Cheng, Z., Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies. Biomaterials 2016, 103, 265-77.

2.         Withana, N. P.#; Saito, T. #; Ma, X. #; Garland, M.; Liu, C.; Kosuge, H.; Amsallem, M.; Verdoes, M.; Ofori, L. O.; Fischbein, M.; Arakawa, M.; Cheng, Z.; McConnell, M. V.; Bogyo, M., Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016, 57 (10), 1583-1590. (# Co-first author)

3.         Withana, N. P. #; Ma, X. #; McGuire, H. M.; Verdoes, M.; van der Linden, W. A.; Ofori, L. O.; Zhang, R.; Li, H.; Sanman, L. E.; Wei, K.; Yao, S.; Wu, P.; Li, F.; Huang, H.; Xu, Z.; Wolters, P. J.; Rosen, G. D.; Collard, H. R.; Zhu, Z.; Cheng, Z.; Bogyo, M., Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Scientific reports 2016, 6, 19755. (# Co-first author)

4.         Sun, Z.; Cheng, K.; Wu, F.; Liu, H.; Ma, X.; Su, X.; Liu, Y.; Xia, L.; Cheng, Z., Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging. Nanoscale 2016, 8 (47), 19644-19653.

5.         Sun, Y.; Ma, X.; Zhang, Z.; Sun, Z.; Loft, M.; Ding, B.; Liu, C.; Xu, L.; Yang, M.; Jiang, Y.; Liu, J.; Xiao, Y.; Cheng, Z.; Hong, X., Preclinical Study on GRPR-Targeted (68)Ga-Probes for PET Imaging of Prostate Cancer. Bioconjugate chemistry 2016, 27 (8), 1857-64.

6.         King, M. T.; Jenkins, C. H.; Sun, C.; Carpenter, C. M.; Ma, X.; Cheng, K.; Le, Q. T.; Sunwoo, J. B.; Cheng, Z.; Pratx, G.; Xing, L., Flexible radioluminescence imaging for FDG-guided surgery. Medical physics 2016, 43 (10), 5298.

7.         Kasten, B. B.; Ma, X.; Cheng, K.; Bu, L.; Slocumb, W. S.; Hayes, T. R.; Trabue, S.; Cheng, Z.; Benny, P. D., Isothiocyanate-Functionalized Bifunctional Chelates and fac-[M(I)(CO)3](+) (M = Re, (99m)Tc) Complexes for Targeting uPAR in Prostate Cancer. Bioconjugate chemistry 2016, 27 (1), 130-42.

8.         Yang, M.; Fan, Q.; Zhang, R.; Cheng, K.; Yan, J.; Pan, D.; Ma, X.; Lu, A.; Cheng, Z., Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging. Biomaterials 2015, 69, 30-7.

9.         Volotskova, O.; Sun, C.; Stafford, J. H.; Koh, A. L.; Ma, X.; Cheng, Z.; Cui, B.; Pratx, G.; Xing, L., Efficient Radioisotope Energy Transfer by Gold Nanoclusters for Molecular Imaging. Small 2015, 11 (32), 4002-8.

10.       Tu, Y.; Liu, L.; Zhao, D.; Liu, Y.; Ma, X.; Fan, Y.; Wan, L.; Huang, T.; Cheng, Z.; Shen, B., Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2. Scientific reports 2015, 5, 13827.

11.       Tao, B.; Cui, M.; Wang, C.; Ma, S.; Wu, F.; Yi, F.; Qin, X.; Liu, J.; Wang, H.; Wang, Z.; Ma, X.; Tian, J.; Chen, Y.; Wang, J.; Cao, F., Percutaneous intramyocardial delivery of mesenchymal stem cells induces superior improvement in regional left ventricular function compared with bone marrow mononuclear cells in porcine myocardial infarcted heart. Theranostics 2015, 5 (2), 196-205.

12.       Sun, Y.; Ma, X.; Cheng, K.; Wu, B.; Duan, J.; Chen, H.; Bu, L.; Zhang, R.; Hu, X.; Deng, Z.; Xing, L.; Hong, X.; Cheng, Z., Strained cyclooctyne as a molecular platform for construction of multimodal imaging probes. Angew Chem Int Ed Engl 2015, 54 (20), 5981-4.

13.       King, M. T.; Carpenter, C. M.; Sun, C.; Ma, X.; Le, Q. T.; Sunwoo, J. B.; Cheng, Z.; Pratx, G.; Xing, L., beta-Radioluminescence Imaging: A Comparative Evaluation with Cerenkov Luminescence Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2015, 56 (9), 1458-64.

14.       Fan, Q.; Cheng, K.; Yang, Z.; Zhang, R.; Yang, M.; Hu, X.; Ma, X.; Bu, L.; Lu, X.; Xiong, X.; Huang, W.; Zhao, H.; Cheng, Z., Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice. Adv Mater 2015, 27 (5), 843-7.

15.       Zhu, X.; Li, J.; Hong, Y.; Kimura, R. H.; Ma, X.; Liu, H.; Qin, C.; Hu, X.; Hayes, T. R.; Benny, P.; Gambhir, S. S.; Cheng, Z., Tc-Labeled Cystine Knot Peptide Targeting Integrin alphabeta for Tumor SPECT Imaging. Molecular pharmaceutics 2014.

16.       Shao, Y.; Liang, W.; Kang, F.; Yang, W.; Ma, X.; Li, G.; Zong, S.; Chen, K.; Wang, J., A direct comparison of tumor angiogenesis with Ga-labeled NGR and RGD peptides in HT-1080 tumor xenografts using microPET imaging. Amino acids 2014.

17.       Shao, Y.; Liang, W.; Kang, F.; Yang, W.; Ma, X.; Li, G.; Zong, S.; Chen, K.; Wang, J., 68Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression. Molecules 2014, 19 (8), 11600-12.

18.       Qin, C.; Liu, H.; Chen, K.; Hu, X.; Ma, X.; Lan, X.; Zhang, Y.; Cheng, Z., Theranostics of malignant melanoma with 64CuCl2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014, 55 (5), 812-7.

19.       Ma, X.; Wang, J.; Cheng, Z., Cerenkov radiation: a multi-functional approach for biological sciences. Frontiers in Physics 2014, 2.

20.       Kasten, B. B. #; Ma, X. #; Liu, H.; Hayes, T. R.; Barnes, C. L.; Qi, S.; Cheng, K.; Bottorff, S. C.; Slocumb, W. S.; Wang, J.; Cheng, Z.; Benny, P. D., Clickable, hydrophilic ligand for fac-[M(I)(CO)3](+) (M = Re/(99m)Tc) applied in an S-functionalized alpha-MSH peptide. Bioconjugate chemistry 2014, 25 (3), 579-92. (# Co-first author)

21.       Kang, F.; Ma, W.; Ma, X.; Shao, Y.; Yang, W.; Chen, X.; Li, L.; Wang, J., Propranolol Inhibits Glucose Metabolism and 18F-FDG Uptake of Breast Cancer Through Posttranscriptional Downregulation of Hexokinase-2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014.

22.       Jiang, L.; Kimura, R. H.; Ma, X.; Tu, Y.; Miao, Z.; Shen, B.; Chin, F. T.; Shi, H.; Gambhir, S. S.; Cheng, Z., A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging. Molecular pharmaceutics 2014.

23.       Fan, Q.; Cheng, K.; Hu, X.; Ma, X.; Zhang, R.; Yang, M.; Lu, X.; Xing, L.; Huang, W.; Gambhir, S. S.; Cheng, Z., Transferring biomarker into molecular probe: melanin nanoparticle as a naturally active platform for multimodality imaging. Journal of the American Chemical Society 2014, 136 (43), 15185-94.

24.       Carpenter, C. M. #; Ma, X. #; Liu, H.; Sun, C.; Pratx, G.; Wang, J.; Gambhir, S. S.; Xing, L.; Cheng, Z., Cerenkov luminescence endoscopy: improved molecular sensitivity with beta--emitting radiotracers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014, 55 (11), 1905-9. (# Co-first author)

25.       Bu, L.; Ma, X.; Tu, Y.; Shen, B.; Cheng, Z., Optical image-guided cancer therapy. Current pharmaceutical biotechnology 2014, 14 (8), 723-32.

26.       Wang, D.; Luo, P.; Wang, Y.; Li, W.; Wang, C.; Sun, D.; Zhang, R.; Su, T.; Ma, X.; Zeng, C.; Wang, H.; Ren, J.; Cao, F., Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism. Diabetes 2013, 62 (5), 1697-708.

27.       Ma, X.; Kang, F.; Xu, F.; Feng, A.; Zhao, Y.; Lu, T.; Yang, W.; Wang, Z.; Lin, M.; Wang, J., Enhancement of cerenkov luminescence imaging by dual excitation of er(3+), yb(3+)-doped rare-Earth microparticles. PloS one 2013, 8 (10), e77926.

28.       Ma, W.; Kang, F.; Wang, Z.; Yang, W.; Li, G.; Ma, X.; Li, G.; Chen, K.; Zhang, Y.; Wang, J., (99m)Tc-labeled monomeric and dimeric NGR peptides for SPECT imaging of CD13 receptor in tumor-bearing mice. Amino acids 2013, 44 (5), 1337-45.

29.       Liu, Y.; Hu, X.; Liu, H.; Bu, L.; Ma, X.; Cheng, K.; Li, J.; Tian, M.; Zhang, H.; Cheng, Z., A comparative study of radiolabeled bombesin analogs for the PET imaging of prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013, 54 (12), 2132-8.

30.       Hu, Z.; Yang, W.; Ma, X.; Ma, W.; Qu, X.; Liang, J.; Wang, J.; Tian, J., Cerenkov luminescence tomography of aminopeptidase N (APN/CD13) expression in mice bearing HT1080 tumors. Molecular imaging 2013, 12 (3), 173-81.

31.       Chen, K.; Ma, W.; Li, G.; Wang, J.; Yang, W.; Yap, L. P.; Hughes, L. D.; Park, R.; Conti, P. S., Synthesis and evaluation of 64Cu-labeled monomeric and dimeric NGR peptides for MicroPET imaging of CD13 receptor expression. Molecular pharmaceutics 2013, 10 (1), 417-27.

32.       Bu, L.; Ma, X.; Tu, Y.; Shen, B.; Cheng, Z., Optical image-guided cancer therapy. Current pharmaceutical biotechnology 2013, 14 (8), 723-32.

33.       Yang, W.; Qin, W.; Hu, Z.; Suo, Y.; Zhao, R.; Ma, X.; Ma, W.; Wang, T.; Liang, J.; Tian, J.; Wang, J., Comparison of Cerenkov luminescence imaging (CLI) and gamma camera imaging for visualization of let-7 expression in lung adenocarcinoma A549 Cells. Nuclear medicine and biology 2012, 39 (7), 948-53.

34.       Sun, D.; Wang, J.; Tian, Y.; Narsinh, K.; Wang, H.; Li, C.; Ma, X.; Wang, Y.; Wang, D.; Li, C.; Wu, J. C.; Tian, J.; Cao, F., Multimodality imaging evaluation of functional and clinical benefits of percutaneous coronary intervention in patients with chronic total occlusion lesion. Theranostics 2012, 2 (8), 788-800.

35.       Hu, Z. #; Ma, X. #; Qu, X.; Yang, W.; Liang, J.; Wang, J.; Tian, J., Three-dimensional noninvasive monitoring iodine-131 uptake in the thyroid using a modified Cerenkov luminescence tomography approach. PloS one 2012, 7 (5), e37623. (# Co-first author)

36.       Hu, Z.; Liang, J.; Yang, W.; Fan, W.; Li, C.; Ma, X.; Chen, X.; Ma, X.; Li, X.; Qu, X.; Wang, J.; Cao, F.; Tian, J., Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation. Optics express 2010, 18 (24), 24441-50.

2002-2007, M.D., Clinical Medicine, Bethune Medical School of Jilin University, China

2013-2015, Exchange Scholar, Molecular Imaging, Stanford University

2010-2016, Ph.D. Radiology, The Fourth Military Medical University, China

2016-2017, Radiologist, Xijin Hospital, Xi'an, China

2017-present, Research Assistant Professor, Cui lab, University of New Mexico, Albuquerque, NM

Education and Appointments

National Natural Science Foundation of China (Grant NO.81501501),A Novel Y-90 Labeled Activatable Smart Probe for Therapy of Cancer Metastasis,2016/01-2018/12,program investigator

Publications

Research Support