Xiaowei Ma, M.D., Ph.D.

Research Assistant Professor

M.D. 2007, Bethune Medical School of Jilin University, China

Exchange Scholar, Molecular Imaging, 2013-15, Stanford University

Ph.D. Radiology, 2016, The Fourth Military Medical University, China

1.         Zhang, R.; Cheng, K.; Antaris, A. L.; Ma, X.; Yang, M.; Ramakrishnan, S.; Liu, G.; Lu, A.; Dai, H.; Tian, M.; Cheng, Z., Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies. Biomaterials 2016, 103, 265-77.

2.         Withana, N. P.#; Saito, T. #; Ma, X. #; Garland, M.; Liu, C.; Kosuge, H.; Amsallem, M.; Verdoes, M.; Ofori, L. O.; Fischbein, M.; Arakawa, M.; Cheng, Z.; McConnell, M. V.; Bogyo, M., Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016, 57 (10), 1583-1590. (# Co-first author)

3.         Withana, N. P. #; Ma, X. #; McGuire, H. M.; Verdoes, M.; van der Linden, W. A.; Ofori, L. O.; Zhang, R.; Li, H.; Sanman, L. E.; Wei, K.; Yao, S.; Wu, P.; Li, F.; Huang, H.; Xu, Z.; Wolters, P. J.; Rosen, G. D.; Collard, H. R.; Zhu, Z.; Cheng, Z.; Bogyo, M., Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Scientific reports 2016, 6, 19755. (# Co-first author)

4.         Sun, Z.; Cheng, K.; Wu, F.; Liu, H.; Ma, X.; Su, X.; Liu, Y.; Xia, L.; Cheng, Z., Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging. Nanoscale 2016, 8 (47), 19644-19653.

5.         Sun, Y.; Ma, X.; Zhang, Z.; Sun, Z.; Loft, M.; Ding, B.; Liu, C.; Xu, L.; Yang, M.; Jiang, Y.; Liu, J.; Xiao, Y.; Cheng, Z.; Hong, X., Preclinical Study on GRPR-Targeted (68)Ga-Probes for PET Imaging of Prostate Cancer. Bioconjugate chemistry 2016, 27 (8), 1857-64.

6.         King, M. T.; Jenkins, C. H.; Sun, C.; Carpenter, C. M.; Ma, X.; Cheng, K.; Le, Q. T.; Sunwoo, J. B.; Cheng, Z.; Pratx, G.; Xing, L., Flexible radioluminescence imaging for FDG-guided surgery. Medical physics 2016, 43 (10), 5298.

7.         Kasten, B. B.; Ma, X.; Cheng, K.; Bu, L.; Slocumb, W. S.; Hayes, T. R.; Trabue, S.; Cheng, Z.; Benny, P. D., Isothiocyanate-Functionalized Bifunctional Chelates and fac-[M(I)(CO)3](+) (M = Re, (99m)Tc) Complexes for Targeting uPAR in Prostate Cancer. Bioconjugate chemistry 2016, 27 (1), 130-42.

8.         Yang, M.; Fan, Q.; Zhang, R.; Cheng, K.; Yan, J.; Pan, D.; Ma, X.; Lu, A.; Cheng, Z., Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging. Biomaterials 2015, 69, 30-7.

9.         Volotskova, O.; Sun, C.; Stafford, J. H.; Koh, A. L.; Ma, X.; Cheng, Z.; Cui, B.; Pratx, G.; Xing, L., Efficient Radioisotope Energy Transfer by Gold Nanoclusters for Molecular Imaging. Small 2015, 11 (32), 4002-8.

10.       Tu, Y.; Liu, L.; Zhao, D.; Liu, Y.; Ma, X.; Fan, Y.; Wan, L.; Huang, T.; Cheng, Z.; Shen, B., Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2. Scientific reports 2015, 5, 13827.

11.       Tao, B.; Cui, M.; Wang, C.; Ma, S.; Wu, F.; Yi, F.; Qin, X.; Liu, J.; Wang, H.; Wang, Z.; Ma, X.; Tian, J.; Chen, Y.; Wang, J.; Cao, F., Percutaneous intramyocardial delivery of mesenchymal stem cells induces superior improvement in regional left ventricular function compared with bone marrow mononuclear cells in porcine myocardial infarcted heart. Theranostics 2015, 5 (2), 196-205.

12.       Sun, Y.; Ma, X.; Cheng, K.; Wu, B.; Duan, J.; Chen, H.; Bu, L.; Zhang, R.; Hu, X.; Deng, Z.; Xing, L.; Hong, X.; Cheng, Z., Strained cyclooctyne as a molecular platform for construction of multimodal imaging probes. Angew Chem Int Ed Engl 2015, 54 (20), 5981-4.

13.       King, M. T.; Carpenter, C. M.; Sun, C.; Ma, X.; Le, Q. T.; Sunwoo, J. B.; Cheng, Z.; Pratx, G.; Xing, L., beta-Radioluminescence Imaging: A Comparative Evaluation with Cerenkov Luminescence Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2015, 56 (9), 1458-64.

14.       Fan, Q.; Cheng, K.; Yang, Z.; Zhang, R.; Yang, M.; Hu, X.; Ma, X.; Bu, L.; Lu, X.; Xiong, X.; Huang, W.; Zhao, H.; Cheng, Z., Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice. Adv Mater 2015, 27 (5), 843-7.

15.       Zhu, X.; Li, J.; Hong, Y.; Kimura, R. H.; Ma, X.; Liu, H.; Qin, C.; Hu, X.; Hayes, T. R.; Benny, P.; Gambhir, S. S.; Cheng, Z., Tc-Labeled Cystine Knot Peptide Targeting Integrin alphabeta for Tumor SPECT Imaging. Molecular pharmaceutics 2014.

16.       Shao, Y.; Liang, W.; Kang, F.; Yang, W.; Ma, X.; Li, G.; Zong, S.; Chen, K.; Wang, J., A direct comparison of tumor angiogenesis with Ga-labeled NGR and RGD peptides in HT-1080 tumor xenografts using microPET imaging. Amino acids 2014.

17.       Shao, Y.; Liang, W.; Kang, F.; Yang, W.; Ma, X.; Li, G.; Zong, S.; Chen, K.; Wang, J., 68Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression. Molecules 2014, 19 (8), 11600-12.

18.       Qin, C.; Liu, H.; Chen, K.; Hu, X.; Ma, X.; Lan, X.; Zhang, Y.; Cheng, Z., Theranostics of malignant melanoma with 64CuCl2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014, 55 (5), 812-7.

19.       Ma, X.; Wang, J.; Cheng, Z., Cerenkov radiation: a multi-functional approach for biological sciences. Frontiers in Physics 2014, 2.

20.       Kasten, B. B. #; Ma, X. #; Liu, H.; Hayes, T. R.; Barnes, C. L.; Qi, S.; Cheng, K.; Bottorff, S. C.; Slocumb, W. S.; Wang, J.; Cheng, Z.; Benny, P. D., Clickable, hydrophilic ligand for fac-[M(I)(CO)3](+) (M = Re/(99m)Tc) applied in an S-functionalized alpha-MSH peptide. Bioconjugate chemistry 2014, 25 (3), 579-92. (# Co-first author)

21.       Kang, F.; Ma, W.; Ma, X.; Shao, Y.; Yang, W.; Chen, X.; Li, L.; Wang, J., Propranolol Inhibits Glucose Metabolism and 18F-FDG Uptake of Breast Cancer Through Posttranscriptional Downregulation of Hexokinase-2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014.

22.       Jiang, L.; Kimura, R. H.; Ma, X.; Tu, Y.; Miao, Z.; Shen, B.; Chin, F. T.; Shi, H.; Gambhir, S. S.; Cheng, Z., A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging. Molecular pharmaceutics 2014.

23.       Fan, Q.; Cheng, K.; Hu, X.; Ma, X.; Zhang, R.; Yang, M.; Lu, X.; Xing, L.; Huang, W.; Gambhir, S. S.; Cheng, Z., Transferring biomarker into molecular probe: melanin nanoparticle as a naturally active platform for multimodality imaging. Journal of the American Chemical Society 2014, 136 (43), 15185-94.

24.       Carpenter, C. M. #; Ma, X. #; Liu, H.; Sun, C.; Pratx, G.; Wang, J.; Gambhir, S. S.; Xing, L.; Cheng, Z., Cerenkov luminescence endoscopy: improved molecular sensitivity with beta--emitting radiotracers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014, 55 (11), 1905-9. (# Co-first author)

25.       Bu, L.; Ma, X.; Tu, Y.; Shen, B.; Cheng, Z., Optical image-guided cancer therapy. Current pharmaceutical biotechnology 2014, 14 (8), 723-32.

26.       Wang, D.; Luo, P.; Wang, Y.; Li, W.; Wang, C.; Sun, D.; Zhang, R.; Su, T.; Ma, X.; Zeng, C.; Wang, H.; Ren, J.; Cao, F., Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism. Diabetes 2013, 62 (5), 1697-708.

27.       Ma, X.; Kang, F.; Xu, F.; Feng, A.; Zhao, Y.; Lu, T.; Yang, W.; Wang, Z.; Lin, M.; Wang, J., Enhancement of cerenkov luminescence imaging by dual excitation of er(3+), yb(3+)-doped rare-Earth microparticles. PloS one 2013, 8 (10), e77926.

28.       Ma, W.; Kang, F.; Wang, Z.; Yang, W.; Li, G.; Ma, X.; Li, G.; Chen, K.; Zhang, Y.; Wang, J., (99m)Tc-labeled monomeric and dimeric NGR peptides for SPECT imaging of CD13 receptor in tumor-bearing mice. Amino acids 2013, 44 (5), 1337-45.

29.       Liu, Y.; Hu, X.; Liu, H.; Bu, L.; Ma, X.; Cheng, K.; Li, J.; Tian, M.; Zhang, H.; Cheng, Z., A comparative study of radiolabeled bombesin analogs for the PET imaging of prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013, 54 (12), 2132-8.

30.       Hu, Z.; Yang, W.; Ma, X.; Ma, W.; Qu, X.; Liang, J.; Wang, J.; Tian, J., Cerenkov luminescence tomography of aminopeptidase N (APN/CD13) expression in mice bearing HT1080 tumors. Molecular imaging 2013, 12 (3), 173-81.

31.       Chen, K.; Ma, W.; Li, G.; Wang, J.; Yang, W.; Yap, L. P.; Hughes, L. D.; Park, R.; Conti, P. S., Synthesis and evaluation of 64Cu-labeled monomeric and dimeric NGR peptides for MicroPET imaging of CD13 receptor expression. Molecular pharmaceutics 2013, 10 (1), 417-27.

32.       Bu, L.; Ma, X.; Tu, Y.; Shen, B.; Cheng, Z., Optical image-guided cancer therapy. Current pharmaceutical biotechnology 2013, 14 (8), 723-32.

33.       Yang, W.; Qin, W.; Hu, Z.; Suo, Y.; Zhao, R.; Ma, X.; Ma, W.; Wang, T.; Liang, J.; Tian, J.; Wang, J., Comparison of Cerenkov luminescence imaging (CLI) and gamma camera imaging for visualization of let-7 expression in lung adenocarcinoma A549 Cells. Nuclear medicine and biology 2012, 39 (7), 948-53.

34.       Sun, D.; Wang, J.; Tian, Y.; Narsinh, K.; Wang, H.; Li, C.; Ma, X.; Wang, Y.; Wang, D.; Li, C.; Wu, J. C.; Tian, J.; Cao, F., Multimodality imaging evaluation of functional and clinical benefits of percutaneous coronary intervention in patients with chronic total occlusion lesion. Theranostics 2012, 2 (8), 788-800.

35.       Hu, Z. #; Ma, X. #; Qu, X.; Yang, W.; Liang, J.; Wang, J.; Tian, J., Three-dimensional noninvasive monitoring iodine-131 uptake in the thyroid using a modified Cerenkov luminescence tomography approach. PloS one 2012, 7 (5), e37623. (# Co-first author)

36.       Hu, Z.; Liang, J.; Yang, W.; Fan, W.; Li, C.; Ma, X.; Chen, X.; Ma, X.; Li, X.; Qu, X.; Wang, J.; Cao, F.; Tian, J., Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation. Optics express 2010, 18 (24), 24441-50.

2002-2007, M.D., Clinical Medicine, Bethune Medical School of Jilin University, China

2013-2015, Exchange Scholar, Molecular Imaging, Stanford University

2010-2016, Ph.D. Radiology, The Fourth Military Medical University, China

2016-2017, Radiologist, Xijin Hospital, Xi'an, China

2017-present, Research Assistant Professor, Cui lab, University of New Mexico, Albuquerque, NM

Education and Appointments

National Natural Science Foundation of China (Grant NO.81501501),A Novel Y-90 Labeled Activatable Smart Probe for Therapy of Cancer Metastasis,2016/01-2018/12,program investigator

Publications

Research Support

© 2015 by Lina Cui Laboratory at the University of Florida, Gainesville, USA